P-174: Good Pregnancy Outcome after Prenatal Exposure to Bleomycin, Etoposide and Cisplatin for Ovarian Immature Teratoma: A Case Report and Literature Review

Background: The administration of bleomycin plus etoposide and cisplatin during pregnancy is rare. Materials and Methods: We describe a case with good pregnancy outcome after exposure to these chemotherapeutic agents at the third trimester of pregnancy. Results: Pregnant woman with stage IIIc immature teratoma underwent surgical staging, and received two cycles of bleomycin, etoposide and cisplatin from the 29th week of pregnancy until delivery. The patient did not have any evidence of recurrence of ovarian cancer for 1.5 years. Her infant did not have any evidence of minor or major malformations, and showed normal neurological development during 1.5 years of follow-up. Conclusion: Germ cell malignant tumors in pregnant women are present at young age. Diagnosis is usually established at approximately 20 weeks of gestational age or after, and pregnancy outcome seems to be favorable after combination therapy with bleomycin, etoposide and cisplatin. However, a definitive conclusion cannot be derived yet because of the limited number of cases currently available in the literature. Further research is needed to acquire more information on the long-term impact of treatment modalities like chemotherapy on the offspring.